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Axel Grothey, MD, Professor of Oncology, Consultant, Medical Oncology, Mayo Clinic, discusses the novel agents being investigated for colorectal cancer (CRC). There has not been a new agent for CRC since the approval of cetuximab and bevacizumab 7 1/2 years ago. In recent months there have been numerous advances in what was previously a very stagnant field. One of the most important discoveries is that KRAS mutated tumors do not respond to epidermal growth factor receptor (EGFR) inhibitor drugs such as cetuximab and panitumumab. Aflibercept, a novel agent currently under investigation, binds to the VEGF-A ligand, VEGF-B, and the placental growth factor (PIGF). Adding aflibercept to FOLFIRI in metastatic CRC patients resulted in significantly improved outcomes in the second-line setting. The oral multikinase inhibitor named regorafenib demonstrated overall survival in heavily pretreated metastatic CRC; these patients currently do not have any clinical options. The data from the phase III trial, which was stopped early because of positive data, will be released at ASCO GI 2012.
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From:OncLiveTV
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| Time:01:48 | More inScience & Technology |
Jogging di Dataran Banting
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From:mustaqeemAlauyun
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| Time:00:20 | More inGaming |
Fast Weight Loss Tips
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bit.ly Here are the top 3 Fast Weight Loss Tips. Find more fitness videos at or own this video for just $0.75! Start your new years resolution off right with a healthy lifestyle diet and exercise plan. These free weight loss diet tips will help you lose fat and weight fast! Happy New Years and clip this video for future art reference. Check Out Diet.com Video! Diet.com: Subscribe to Our YouTube Channel – Go behind the scenes w/ Sarah's Blog- Twitter twitter.com Facebook: iTunes: tinyurl.com Cool!
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From:slimmingnowon
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| Time:03:10 | More inEntertainment |
colon-yo soy asi !!!!
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From:fotosdecolon
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4 2
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| Time:00:48 | More inSports |
Discover a Colon Cleanser to Detoxify the Body.
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CLICK HERE mhlnk.com and get your FREE bottle delivered straight to your door, click on the link above.
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From:colonkev2011
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| Time:00:54 | More inPeople & Blogs |
Supreme Solution Body Moisturizers
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www.herbalix.com Organic and natural intensive body moisturizers and oils from Herbalix.
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From:HerbalixPro
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| Time:02:15 | More inHowto & Style |
BabyTapBook Promo video
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This app was created to give babies and young children the opportunity to learn new words and explore the world as a whole by simply tapping on objects that interest them. Utilizing a "baby safe" Play mode that makes accidentally exiting the app nearly impossible, youngsters are presented with a grid of interactive tiles. Each tile includes a unique image which when touch will expand to full screen, featuring corresponding audio effects with an added tap as well. BabyTapBook includes a number of diverse categories to explore, ranging from Animals and Colors, to Christmas themes, Instruments and more. Users can easily browse through these categories with a simple swipe of the hand left or right at the top of their screen while in Play mode. *** Capture Memorable Moments & Let Kids Record the World! *** A kid-friendly Video mode allows users to record movies with their device in 30 second clips absolutely free of charge. Only available with a front face camera: Unique video recording feature that allows parents to capture video automatically as a child playing with the app and not being aware that he or she is being recorded. Enjoy and share videos of your adorable child with her / him playing completely natural in front of your iPhone's camera. Created videos are automatically saved to the user's photo library, where they can be edited or shared with friends via Facebook or Youtube. *** Kids Come First, But Parents Stay in Control *** Realizing the importance of Parental <b>…</b>
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From:babytapbook
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| Time:01:55 | More inFilm & Animation |